Characterization of the ‘White’ appearing clots that cause acute ischemic stroke
| Autor: | Paul Brennan, Katarina Jood, John Thornton, Sarah Power, Klearchos Psychogios, Petra Redfors, András Nagy, Rosanna Rossi, Ágnes Vadász, Karen M. Doyle, Seán Fitzgerald, István Szikora, Turgut Tatlisumak, Oana Madalina Mereuta, Ray McCarthy, Waleed Brinjikji, Abhay Pandit, Michael Gilvarry, Alan O'Hare, Dennis Dunker, Georgios Magoufis, Georgios Tsivgoulis, Andrew Douglas, Eric Ceder, Sara Molina Gil, Annika Nordanstig, David F. Kallmes, Alexandros Rentzos |
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| Přispěvatelé: | Science Foundation Ireland, European Regional Development Fund, National Institutes of Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
Platelets Pathology medicine.medical_specialty Macroscopic appearance Fibrin Cohort Studies Calcification Physiologic Von Willebrand factor medicine.artery Occlusion von Willebrand Factor Medicine Humans Platelet Acute ischemic stroke Computed tomography angiography Ischemic stroke biology medicine.diagnostic_test business.industry Rehabilitation Thrombosis medicine.disease Middle cerebral artery biology.protein Surgery Neurology (clinical) Collagen Cardiology and Cardiovascular Medicine business Mechanical thrombectomy Calcification circulatory and respiratory physiology |
| Popis: | Objectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the composition, imaging and procedural characteristics of ‘white’ clots retrieved by mechanical thrombectomy. Materials and methods Seventy five ‘white’ thrombi were selected by visual inspection from a cohort of 760 clots collected as part of the RESTORE registry. Clots were evaluated histopathologically. Results Quantification of Martius Scarlett Blue stain identified platelets/other as the major component in ‘white’ clots’ (mean of 55% of clot overall composition) followed by fibrin (31%), red blood cells (6%) and white blood cells (3%). ‘White’ clots contained significantly more platelets/other (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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