Reversion from prediabetes to normoglycaemia after weight change in older persons: the KORA F4/FF4 study
| Autor: | Christa Meisinger, Oliver Kuss, Andreas Stang, Cornelia Huth, Wolfgang Rathmann, Barbara Thorand, Michael Roden, Annette Peters, Bernd Kowall, Christian Herder |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Waist Time Factors Endocrinology Diabetes and Metabolism Population Medizin Reversion Medicine (miscellaneous) 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Risk Assessment Body Mass Index Prediabetic State 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Germany Weight Loss Medicine Humans Prediabetes Obesity Prospective Studies education Aged Glycated Hemoglobin education.field_of_study Nutrition and Dietetics business.industry Weight change Remission Induction Middle Aged medicine.disease Heart Disease Risk Factors Female medicine.symptom Waist Circumference Cardiology and Cardiovascular Medicine business Body mass index Risk Reduction Behavior Biomarkers Cohort study |
| Popis: | In a non-interventional study of older persons, we assessed the impact of changes in BMI and waist circumference (WC) on reversion from glucose- and HbA1c-defined prediabetes to normoglycaemia (in short: reversion) and on persistence of normoglycaemia. Moreover, we studied whether reversion reduced cardiovascular risk.From the population-based KORA S4/F4/FF4 cohort study conducted in Southern Germany, we utilized data from the second and third visit to the study center (median follow-up 6.5 years). We used two overlapping data sets, one with 563 persons with HbA1c6.5% (mean age 69 years, 51.5% men), one with 510 persons with glucose-based prediabetes or normal glucose tolerance. We calculated proportions of reversion, and estimated adjusted relative risks for the association between initial BMI/WC and change of BMI/WC, respectively, and reversion (and persistence of normoglycaemia, respectively). We estimated 10-year cardiovascular risks using the Framingham 2008 score. Overall, 27.3% of persons with HbA1c-defined prediabetes and 9.2% of persons with glucose-based prediabetes returned to normoglycaemia during follow-up. Lower initial BMI/WC and reduction of BMI/WC were associated with larger probabilities of returning to normoglycaemia (e.g., for HbA1c 5.7-6.4%, RR = 1.24 (95% CI: 1.09-1.41) per 1 kg/mIn older adults, even moderate weight reduction contributes to reversion from prediabetes to normoglycaemia and to maintaining normoglycaemia. |
| Databáze: | OpenAIRE |
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