Shattering the castle walls: Anti-stromal therapy for pancreatic cancer

Autor: Hulya Ertas, Ozkan Kanat
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı., Kanat, Özkan, Ertaş, Hülya
Rok vydání: 2018
Předmět:
0301 basic medicine
Cancer therapy
FOLFIRINOX
Hedgehog signaling
Stroma
Cancer
Chronic Pancreatitis
Acinar Cells
Retinol derivative
Cancer growth
0302 clinical medicine
Osteonectin
Gene-expression
Pancreas cancer
Hyaluronan
Priority journal
Carcinoma cells
Gastroenterology
MicroRNA
Minireviews
Tumor progression
Oncology
030220 oncology & carcinogenesis
Cell interaction
Stellate cells
Pancreatic stellate cell
Human
medicine.drug
Stromal cell
Hyaluronic acid
Nab-paclitaxel
03 medical and health sciences
Targeted therapies
Vitamin D derivative
Upregulation
Pancreatic cancer
Retinoic acid
medicine
Secreted protein acidic and rich in cysteine
Angiotensin 2 receptor antagonist
Ductal adenocarcinoma
business.industry
Sparc expression
Nonhuman
medicine.disease
Antifibrotic agent
Gemcitabine
Oxaliplatin
Irinotecan
030104 developmental biology
Cancer cell
Patient survival
Cancer research
business
Gastroenterology & hepatology
Short survey
Zdroj: World Journal of Gastrointestinal Oncology
ISSN: 1948-5204
DOI: 10.4251/wjgo.v10.i8.202
Popis: Despite the availability of potent chemotherapy regimens, such as 5-fluorouracil, folinic acid, irinotecan, and oxaliplatin (FOLFIRINOX) and nab-paclitaxel plus gemcitabine, treatment outcomes in metastatic pancreatic cancer (PC) remain unsatisfactory. The presence of an abundant fibrous stroma in PC is considered a crucial factor for its unfavorable condition. Apparently, stroma acts as a physical barrier to restrict intratumoral cytotoxic drug penetration and creates a hypoxic environment that reduces the efficacy of radiotherapy. In addition, stroma plays a vital supportive role in the development and progression of PC, which has prompted researchers to assess the potential benefits of agents targeting several cellular (e.g., stellate cells) and acellular (e.g., hyaluronan) elements of the stroma. This study aims to briefly review the primary structural properties of PC stroma and its interaction with cancer cells and summarize the current status of anti-stromal therapies in the management of metastatic PC.
Databáze: OpenAIRE
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