Concentrations of plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in induced sputum of asthma patients after allergen challenge
| Autor: | S. Zukowski, Marcin Moniuszko, Anna Bodzenta-Lukaszyk, Krzysztof Kowal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Histology Adolescent Plasmin medicine.medical_treatment Inflammation urokinase Pathology and Forensic Medicine chemistry.chemical_compound plasminogen activator inhibitor Internal medicine Plasminogen Activator Inhibitor 1 medicine Animals Humans Antigens Dermatophagoides lcsh:QH573-671 Saline Asthma House dust mite biology lcsh:Cytology Pyroglyphidae Sputum General Medicine allergen challenge Eosinophil Allergens medicine.disease biology.organism_classification Urokinase-Type Plasminogen Activator respiratory tract diseases medicine.anatomical_structure Endocrinology chemistry Plasminogen activator inhibitor-1 Immunology medicine.symptom medicine.drug |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 518-523 (2011) Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 518-523 (2010) |
| ISSN: | 1897-5631 0239-8508 |
| Popis: | Urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) are involved in tiisue remodeling and repair processes associated with acute and chronic inflammation. The aim of the study was to evaluate the effect of allergen challenge on concentration of uPA and PAI-1 in induced sputum of house dust mite allergic asthmatics (HDM-AAs). Thirty HDM-AAs and ten healthy persons (HCs)were recruited for the study. In 24 HDM-AAs bronchial challenge with Dermatophagoides pteronyssinus (Dp) and in 6 HDM-AAs sham challenege with saline were performed. In HDM-AAs sputum was induced 24 hours before (T0) and 24 hours (T24) after the challenge. Concentration of uPA and PAI-1 in induced sputum were determined using immunoenzymatic assays. At T0 in HDM-AAs mean sputum uPA (151 Âą 96 pg/ml) and PAI-1 (4341 Âą 1262 pg/ml) concentrations were higher than in HC (18.8 Âą 6.7 pg/ml; p=0.0002 and 596 Âą 180 pg/ml; p |
| Databáze: | OpenAIRE |
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