Exercise-induced increments in plasma levels of propranolol and noradrenaline
| Autor: | Jerry G. Webb, Herman B. Daniell, T E Gaffney, L A Gourley, Thomas Walle, G A Hurwitz, S A Bai, C Boyd Loadholt |
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| Rok vydání: | 1983 |
| Předmět: |
Pharmacology
medicine.medical_specialty Total plasma Chemistry Physical Exertion Physical exercise Plasma levels Propranolol Placebo Norepinephrine (medication) Norepinephrine Endocrinology Internal medicine Blood plasma medicine Humans Pharmacology (medical) Plasma Volume Volunteer Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 16:599-608 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1983.tb02228.x |
| Popis: | Exercise-induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise-induced increments of 13 +/- 4% at 4 h after the last dose, 18 +/- 7% at 9 h and 41 +/- 5% at 16 h. Exercise-induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise-induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action. |
| Databáze: | OpenAIRE |
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