A single center’s experience using four different front line mobilization strategies in lymphoma patients planned to undergo autologous hematopoietic cell transplantation

Autor: Ying Huang, Leslie A. Andritsos, Bradley M. Haverkos, Sumithra Vasu, Lynn O'Donnell, Steve Devine, Samantha Jaglowski, Sam Penza, B Whittaker, Patrick Elder, Diane Scholl
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Oncology
Male
Benzylamines
Lymphoma
medicine.medical_treatment
Antigens
CD34
Cell Count
Hematopoietic stem cell transplantation
Single Center
Cyclams
0302 clinical medicine
Heterocyclic Compounds
Granulocyte Colony-Stimulating Factor
Prospective Studies
Mobilization
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
chemomobilization
Hematopoietic Stem Cell Mobilization
3. Good health
Granulocyte colony-stimulating factor
030220 oncology & carcinogenesis
Female
medicine.drug
Adult
medicine.medical_specialty
Antineoplastic Agents
Transplantation
Autologous
Article
03 medical and health sciences
Young Adult
Internal medicine
medicine
Humans
mobilization
Aged
Transplantation
business.industry
Plerixafor
plerixafor
medicine.disease
Hematopoietic Stem Cells
stem cell
Immunology
business
030215 immunology
Zdroj: Bone marrow transplantation
ISSN: 1476-5365
0268-3369
Popis: In an otherwise eligible patient with relapsed lymphoma, inadequate mobilization of peripheral blood stem cells is a limiting factor to proceeding with an autologous hematopoietic cell transplantation (auto-HCT). Multiple strategies have been used to mobilize an adequate number of hematopoietic stem cells (HSCs) with no obvious front-line strategy. We report a single institutional experience mobilizing HSCs using four different approaches in lymphoma patients. We prospectively collected mobilization outcomes on patients planning to undergo auto-HCT at Ohio State University. We report results of first mobilization attempt for all relapsed or refractory lymphoma patients between 2008–2014. We identified 255 lymphoma patients who underwent mobilization for planned auto-HCT. The 255 lymphoma patients underwent the following front line mobilization strategies: 95 (37%) GCSF alone, 38 (15%) chemomobilization (GCSF+chemotherapy), 97 (38%) preemptive day 4 plerixafor, and 25 (10%) rescue day 5 plerixafor. As expected, there were significant differences between cohorts including age, comorbid indices, histology, and amount of prior chemotherapy. After controlling for differences between groups, the odds of collecting 2×106/kg HSCs on the first day of collection and 5×106/kg HSCs in total was highest in the cohort undergoing chemomobilization. In conclusion, our experience highlights the effectiveness of chemomobilization.
Databáze: OpenAIRE
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