Quinidine-induced hepatitis. A common and reversible hypersensitivity reaction
| Autor: | Hilla Knobler, Itzhak S. Levij, Tova Chajek-Shaul, Dov Gavish |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Gastroenterology Medical Records Drug Hypersensitivity Sex Factors Liver Function Tests Internal medicine Internal Medicine Humans Medicine Aged Retrospective Studies Hepatitis medicine.diagnostic_test business.industry Hepatobiliary disease Hepatitis A Middle Aged medicine.disease Quinidine Rash Hypersensitivity reaction Liver Liver biopsy Female Liver function Chemical and Drug Induced Liver Injury medicine.symptom business Liver function tests |
| Zdroj: | Archives of Internal Medicine. 146:526-528 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.146.3.526 |
| Popis: | • In a retrospective survey of drug-induced hepatitis during a ten-year period, we found that quinidine sulfate was the most common offending agent. We analyzed the clinical and laboratory data of the 33 cases of quinidine-induced hepatitis and noted the following: (1) It is an easily recognized drug reaction, because, in most patients, fever preceded liver damage. (2) The clinical picture usually includes fever and sometimes is accompanied by gastrointestinal symptoms, rash, and thrombocytopenia, which resolved after discontinuation of drug therapy, but reappeared promptly after a rechallenge. (These features suggest a hypersensitivity mechanism.) (3) The histologic findings of the liver biopsy specimens consisted of portal and parenchymal, acute and chronic hepatitis, combined with granulomas. (4) In a long-term follow-up study of 15 patients, no liver function abnormalities were found. We thus conclude that quinidine-induced hepatitis, when recognized early, is a reversible drug reaction. (Arch Intern Med1986;146:526-528) |
| Databáze: | OpenAIRE |
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