Growth Hormone (GH) and Gonadotropin-Releasing Hormone (GnRH) in the Central Nervous System: A Potential Neurological Combinatory Therapy?

Autor: Steve Harvey, Carlos Arámburo, Denisse Calderón-Vallejo, Carlos G. Martínez-Moreno, José Luis Quintanar
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Central Nervous System
Hippocampus
Gonadotropin-releasing hormone
Review
Gonadotropin-Releasing Hormone
lcsh:Chemistry
0302 clinical medicine
Central Nervous System Diseases
lcsh:QH301-705.5
Spectroscopy
neuroregeneration
biology
General Medicine
neurotrophic
3. Good health
Computer Science Applications
GH
medicine.anatomical_structure
Neuroprotective Agents
Hypothalamus
extrapituitary
Drug Therapy
Combination
neuroprotection
CNS
hormones
hormone substitutes
and hormone antagonists
Neurotrophin
medicine.medical_specialty
endocrine system
Central nervous system
Neuroprotection
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
therapy
business.industry
Organic Chemistry
extrahypothalamic
Neuroregeneration
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
Growth Hormone
GnRH
biology.protein
business
030217 neurology & neurosurgery
Hormone
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 2, p 375 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: This brief review of the neurological effects of growth hormone (GH) and gonadotropin-releasing hormone (GnRH) in the brain, particularly in the cerebral cortex, hypothalamus, hippocampus, cerebellum, spinal cord, neural retina, and brain tumors, summarizes recent information about their therapeutic potential as treatments for different neuropathologies and neurodegenerative processes. The effect of GH and GnRH (by independent administration) has been associated with beneficial impacts in patients with brain trauma and spinal cord injuries. Both GH and GnRH have demonstrated potent neurotrophic, neuroprotective, and neuroregenerative action. Positive behavioral and cognitive effects are also associated with GH and GnRH administration. Increasing evidence suggests the possibility of a multifactorial therapy that includes both GH and GnRH.
Databáze: OpenAIRE
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