Preimplantation genetic diagnosis to improve pregnancy outcomes in subfertility
| Autor: | M D Joe Leigh Simpson, M D and Joe Leigh Simpson |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Infertility
Male medicine.medical_specialty Abortion Habitual Blastomeres Reproductive Techniques Assisted Aneuploidy Chromosomal translocation Reproductive technology Polar Bodies Preimplantation genetic diagnosis Sensitivity and Specificity Pregnancy medicine Humans In Situ Hybridization Fluorescence Preimplantation Diagnosis Chromosome Aberrations Comparative Genomic Hybridization Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology General Medicine medicine.disease Embryo transfer Blastocyst Female Safety business Comparative genomic hybridization |
| Zdroj: | Best practiceresearch. Clinical obstetricsgynaecology. 26(6) |
| ISSN: | 1532-1932 |
| Popis: | Pre-implantation genetic diagnosis provides prenatal genetic diagnosis before implantation, thus allowing detection of chromosomal abnormalities and their exclusion from embryo transfer in assisted reproductive technologies. Polar body, blastomere or trophectoderm can each be used to obtain requisite genetic or embryonic DNA. Pre-implantation genetic diagnosis for excluding unbalanced translocations is well accepted, and pre-implantation genetic diagnosis aneuploidy testing to avoid repeated pregnancy losses in couples having recurrent aneuploidy is efficacious in reducing miscarriages. Controversy remains about whether pre-implantation genetic diagnosis aneuploidy testing improves take home pregnancy rates, for which reason adherence to specific indications is recommended while the issue is being adjudicated. Current recommendations are for obligatory 24 chromosome testing, most readily using array comparative genome hybridisation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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