Validity of new methods to evaluate renal function in cancer patients treated with cisplatin

Autor: Naoko Chayahara, Naoki Otsuki, T. Shimada, Yohei Funakoshi, Yoshinori Imamura, Hideo Tomioka, Yutaka Fujiwara, Ken-ichi Nibu, Toru Mukohara, Michio Umezu, Hironobu Minami, Naomi Kiyota, Masanori Toyoda
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Cancer Research
Cancer chemotherapy
Toxicology
urologic and male genital diseases
Kidney Function Tests
0302 clinical medicine
Japan
Neoplasms
Epidemiology
Pharmacology (medical)
030212 general & internal medicine
Estimated glomerular filtration rate
Renal Insufficiency
reproductive and urinary physiology
Aged
80 and over
integumentary system
Inulin
Inulin clearance
Middle Aged
female genital diseases and pregnancy complications
Oncology
030220 oncology & carcinogenesis
Creatinine
Original Article
Urine collection
medicine.drug
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Metabolic Clearance Rate
Urology
Renal function
Antineoplastic Agents
03 medical and health sciences
Internal medicine
medicine
Humans
Aged
Cisplatin
Pharmacology
Dose-Response Relationship
Drug
business.industry
urogenital system
With glomerular filtration rate
fungi
Cancer
Reproducibility of Results
Cancer patients
medicine.disease
Creatinine clearance
Renal Elimination
Endocrinology
business
Biomarkers
Kidney disease
Zdroj: Cancer Chemotherapy and Pharmacology
ISSN: 1432-0843
0344-5704
Popis: Purpose Creatinine clearance (Ccr) is used as a marker of renal function in cancer chemotherapy, but it is not correlated with glomerular filtration rate (GFR) after high-dose cisplatin treatment. In addition to Ccr, measured using 24-h urine collection (24-h Ccr) or Cockcroft–Gault formula (CGF), the Chronic Kidney Disease Epidemiology Collaboration (CKD–EPI) equation and the Japanese GFR estimation equation (the Japanese equation) have been recently developed to estimate GFR for predicting renal function. However, these equations remain to be evaluated, particularly in cancer patients treated with cisplatin. Therefore, we investigated the validity of these equations for predicting the GFR in cancer patients treated with cisplatin. Methods GFR was measured by inulin clearance (Cin) in 50 cancer patients and compared with GFR estimated by the CKD–EPI equation, the Japanese equation, and Ccr estimated by CGF or measured by 24-h Ccr before the first and third cisplatin-containing chemotherapy cycles (considered pretreatment and posttreatment, respectively). Results Before treatment, the CKD–EPI and the Japanese equations estimated GFR with higher accuracy than Ccr. Posttreatment bias values for GFR estimation using the CKD–EPI and the Japanese equations were lower than those for Ccr. The CKD–EPI and the Japanese equations were also more precise than Ccr. However, for patients with low renal function, these equations still overestimated Cin. Conclusion The CKD–EPI and the Japanese equations estimated GFR with lower bias and higher precision than Ccr pre- and postcisplatin treatment. This study is registered at UMIN: 000002167.
Databáze: OpenAIRE
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