Dynamics of activity of monoamine oxidase B and antioxidant defense enzymes in human brain during postnatal ontogeny
| Autor: | S. E. Shemyakov, O. V. Shumeleva, N. V. Malinovskaya, I. A. Volchegorskii |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Cerebellum medicine.medical_specialty Adolescent Ontogeny Thalamus Biology medicine.disease_cause Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Fetus Internal medicine medicine Humans Child Monoamine Oxidase Superoxide Dismutase Age Factors Infant Newborn Brain Ceruloplasmin Infant General Medicine Human brain Catalase Oxidative Stress medicine.anatomical_structure Endocrinology nervous system Child Preschool Forebrain biology.protein Monoamine oxidase B Oxidative stress |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 142:194-201 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-006-0326-6 |
| Popis: | During postnatal development, activity of monoamine oxidase B in human brain structures increases, while activity of Cu,Zn-dependent SOD decreases with compensatory increase in catalase activity and ceruloplasmin content. Under these conditions, the resistance of the pontobulbar structures and thalamus to oxidative stress decreases at the age of 1-12 years and returned to the prenatal level during adolescence. The increase in catalase activity is most pronounced in structures of the forebrain (cortex and neostriatum), cerebellum, and hypothalamus; it is accompanied by ontogenetic increase in oxidative stress resistance, which is maximum at the age of 12-21 years. The maintenance of resistance to oxidative stress (depends on monoamine oxidase B) can be considered as an important condition of structural and functional maturation of cerebral structures during the postnatal ontogeny. |
| Databáze: | OpenAIRE |
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