A Prospective Cohort Study of the Prevalence of Growth, Facial, and Central Nervous System Abnormalities in Children with Heavy Prenatal Alcohol Exposure
| Autor: | James Troendle, Sofía Aros, Nancy Unanue, James L. Mills, Barbara Conca, Devon Kuehn, Mary Conley, María de los Angeles Avaria, Cecilia Henriquez, Fernando Cassorla, Karin Kleinsteuber, Tonia C. Carter, Alejandra Avila |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Alcohol Drinking Birth weight Population Fetal alcohol syndrome Medicine (miscellaneous) Binge drinking Nervous System Malformations Toxicology Article Developmental psychology Cohort Studies Craniofacial Abnormalities Young Adult Pregnancy Prevalence medicine Birth Weight Humans Abnormalities Multiple Prospective Studies Child Prospective cohort study education education.field_of_study business.industry Infant Newborn Facies Infant medicine.disease Frontal Lobe Muscular Atrophy Psychiatry and Mental health Low birth weight Fetal Alcohol Spectrum Disorders Child Preschool Prenatal Exposure Delayed Effects Female medicine.symptom business Follow-Up Studies Cohort study |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 36:1811-1819 |
| ISSN: | 0145-6008 |
| DOI: | 10.1111/j.1530-0277.2012.01794.x |
| Popis: | Although prenatal exposure to alcohol is the most common environmental cause of intellectual impairment, the vast majority, 90 to 95%, of children exposed to large quantities of alcohol in utero do not develop fetal alcohol syndrome (FAS; Cronk and Weiss, 2007; Ornoy and Ergaz, 2010). FAS is characterized by abnormalities in 3 areas—growth restriction, central nervous system (CNS) impairment, and a distinctive pattern of dysmorphic facial features. Fetal alcohol spectrum disorders (FASD) is an umbrella term used to define the full spectrum of adverse outcomes that can be associated with prenatal alcohol exposure. Diagnostic classifications such as FAS, partial fetal alcohol syndrome (PFAS), and alcohol-related neurodevelopmental disorders fall under the umbrella of FASD. Establishing population-based prevalence and other epidemiologic characteristics of FASD has been a challenge owing to limitations in prenatal screening, variations in methodology, and incomplete data (May et al., 2009). Moreover, there is limited information available on how quantity and patterns of alcohol intake influence the likelihood that a child will develop FAS or other outcomes under the umbrella of FASD. Animal models have suggested that the peak blood alcohol concentration is correlated with damage to the fetus (Bonthius et al., 1988; Gladstone et al., 1996; Maier et al., 1995). A systematic review of the effects of binge drinking during pregnancy in humans found no convincing evidence that it increased the risk of low birth weight, growth restriction, or birth defects, but could not rule out a possible effect on neurodevelopmental outcome (Henderson et al., 2007). In the current study, we prospectively identified a cohort of pregnant women consuming large amounts of alcohol during pregnancy and followed their children for up to 8.5 years to evaluate the prevalence of growth restriction, CNS abnormalities, and facial dysmorphology. Detailed alcohol data were collected during the pregnancy to determine how the quantity and pattern of maternal alcohol consumption affected each of these adverse child outcomes. |
| Databáze: | OpenAIRE |
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