Consummatory Successive Negative Contrast in Rats

Autor:	Mauricio R. Papini, Ana Vázquez-Ágredos, Leandro Ruiz-Leyva, Ignacio Morón, Cruz Miguel Cendán, Ana María Jiménez-García, Carmen Torres
Rok vydání:	2019
Předmět:	medicine.medical_specialty Hypoalgesia Strategy and Management Mechanical Engineering Addiction media_common.quotation_subject Metals and Alloys Audiology Industrial and Manufacturing Engineering Negative contrast Animal model Sucrose solution Methods Article medicine media_common
Zdroj:	Bio Protoc
ISSN:	2331-8325
DOI:	10.21769/bioprotoc.3201
Popis:	Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and increase oral ethanol consumption in rats. The procedure is based on exposing the experimental animals to a 32% sucrose solution during several sessions (preshift sessions) followed by a devaluation to 4% sucrose during the next few sessions (postshift sessions). The cSNC effect can be monitored by comparing the experimental group to an unshifted control that had access to 4% sucrose throughout the entire experiment (preshift and postshift sessions). The cSNC phenomenon is defined by lower consumption of sucrose in the downshifted group than in the unshifted group during postshfit sessions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f4e7f27930bda2c467c6001c613e3b https://doi.org/10.21769/bioprotoc.3201 Zobrazit plný text záznamu