Is the brain spared in Crimean-Congo haemorrhagic fever? An MR-SWI study to reveal CNS involvement
| Autor: | Bilge Öztoprak, Aynur Engin, Ibrahim Oztoprak |
|---|---|
| Přispěvatelé: | [Oztoprak, Bilge -- Oztoprak, Ibrahim] Cumhuriyet Univ, Dept Radiol, Sch Med, Sivas, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sivas, Turkey, Oztoprak, Bilge -- 0000-0002-1773-9608 |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent 030106 microbiology Central nervous system Disease Severity of Illness Index 03 medical and health sciences Young Adult Magnetic resonance imaging medicine Humans Radiology Nuclear Medicine and imaging Encephalitis Viral Prospective Studies Prospective cohort study Neuroradiology Aged Cerebral Hemorrhage Aged 80 and over medicine.diagnostic_test business.industry Viral encephalitis Brain Interventional radiology General Medicine Middle Aged medicine.disease medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Haemorrhage Nairovirus Hemorrhagic Fever Virus Crimean-Congo Female Hemorrhagic Fever Crimean Radiology business Encephalitis |
| Zdroj: | European radiology. 28(9) |
| ISSN: | 1432-1084 |
| Popis: | WOS: 000440984300036 PubMed ID: 29532238 The aim of this prospective study is to investigate the central nervous system involvement in Crimean-Congo haemorrhagic fever (CCHF) with magnetic resonance imaging (MRI) in conjunction with clinical and laboratory findings. Between July 2015 and August 2016, 36 patients with CCHF were undergone brain MRI including SWI. Two MRIs, one at the time of admission and the second in the convalescent period, were performed for each patient in order to see if there is any sign of central nervous system (CNS) involvement, especially in terms of intracranial haemorrhage or viral encephalitis. Clinical severity scoring was also done and laboratory findings were noted in order to correlate with clinical and imaging findings. None of the 36 patients showed any MRI findings of an acute intracranial event during the course of the disease. There was a significant difference between mild cases and moderate cases in terms of some laboratory parameters (p < 0.05). Although CCHF is a highly lethal disease which involves multiple organs and systems, CNS involvement seems to be extremely rare in mild and moderate cases. aEuro cent MRI is the imaging method of choice to diagnose microbleeds and encephalitis aEuro cent Although CCHF causes multisystem bleeding, intracranial haemorrhage seems to be very rare aEuro cent CNS complications are uncommon, even in the setting of suggestive symptoms aEuro cent Death usually results from extracranial bleeding and multiorgan failure aEuro cent Severity scoring is associated with some laboratory abnormalities in CCHF. Scientific Research Projects program of Cumhuriyet University (CUBAP), Sivas, Turkey This study has received funding by Scientific Research Projects program of Cumhuriyet University (CUBAP), Sivas, Turkey. |
| Databáze: | OpenAIRE |
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