Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain

Autor: Lynne J. Williams, Ursula Brain, Tim F. Oberlander, Ruth E. Grunau, Naznin Virji-Babul, Bruce Bjornson, Naama Rotem-Kohavi, Janet F. Werker, Steven P. Miller
Rok vydání: 2018
Předmět:
Adult
Cognitive Neuroscience
Serotonin reuptake inhibitor
Physiology
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Pregnancy
mental disorders
Neural Pathways
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Maternal-Fetal Exchange
Biological Psychiatry
Depression (differential diagnoses)
Psychiatric Status Rating Scales
Fetus
Brain Mapping
Resting state fMRI
medicine.diagnostic_test
business.industry
Mood Disorders
05 social sciences
Infant
Newborn
Brain
medicine.disease
Magnetic Resonance Imaging
In utero
Prenatal Exposure Delayed Effects
Female
Neurology (clinical)
Serotonin
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Selective Serotonin Reuptake Inhibitors
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging. 4(1)
ISSN: 2451-9030
Popis: Background Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin reuptake, and thereby are thought to alter central fetal serotonin signaling. Both prenatal maternal mood disturbances and in utero SSRI exposure have been associated with altered fetal and infant behavior. Resting-state functional magnetic resonance imaging has identified resting-state networks (RSNs) in newborns, reflecting functional capacity of auditory and visual networks and providing opportunities to examine early experiences effects on neurodevelopment. We sought to examine the effect of in utero SSRI exposure on neonatal RSN functional organization. We hypothesized that prenatal SSRI exposure would be associated with alterations in neonatal RSNs compared with healthy control infants and infants exposed to mothers with depression. Methods Clinician-rated Hamilton Depression Rating Scale and self-reported Pregnancy Experiences Scale were completed during the third trimester. Control (n = 17), maternal depression–exposed (Hamilton Depression Rating Scale ≥8 without SSRI exposure, n = 16), and SSRI-exposed (n = 20) 6-day-old neonates underwent resting-state functional magnetic resonance imaging. Independent component analysis was used as a data-driven approach to extract 22 RSNs. Results SSRI-exposed neonates had higher connectivity in a putative auditory RSN compared with depressed-only (p = .01) and control (p = .02) infants (corrected for multiple comparisons), controlling for sex, age at the magnetic resonance imaging, and Pregnancy Experiences Scale score. Conclusions Hyperconnectivity in auditory RSN in neonates with in utero SSRI exposure relative to neonates of depressed but not pharmacologically treated mothers and control infants may offer an insight into the functional organization origins of shifts in language perception and altered language development, previously reported in infants and children with prenatal SSRI exposure.
Databáze: OpenAIRE
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