The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises

Autor:	C. H. Clark, R. C. Wilson, Elliott R. Jacobson, George V. Kollias, R. Caligiuri, B. McNAB
Rok vydání:	1990
Předmět:	Pharmacology Volume of distribution General Veterinary Chemistry Residence time Temperature Area under the curve Turtles Clearance time Oxygen Consumption Animal science Pharmacokinetics Amikacin Anesthesia medicine Animals Tissue Distribution Clearance rate medicine.drug
Zdroj:	Journal of Veterinary Pharmacology and Therapeutics. 13:287-291
ISSN:	1365-2885 0140-7783
DOI:	10.1111/j.1365-2885.1990.tb00778.x
Popis:	Caligiuri, R., Kollias, G.V., Jacobson, E., McNab, B., Clark, C.H. & Wilson, R.C. The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises. J. vet. Pharmacol. Therap. 13, 287–291. The pharmacokinetics of amikacin were compared in two groups of tortoises, one held at 20dC and the other at 30dC. The mean (± SD) residence time for amikacin in the 30dC tortoises was 22.67±0.50 h; significantly (P 0.05) in the steady-state volume of distribution (Vd(ss)) between the tortoises held at 30dC (0.241±0.520 l/kg) and those held at 20dC (0.221±0.019 l/kg). The clearance rate was faster (P
Databáze:	OpenAIRE
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