Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds
| Autor: | Duangjai Tungmunnithum, Benoît Maunit, Sullivan Renouard, Bilal Haider Abassi, Emilie Leclerc, Cyrielle Corbin, Ophélie Fliniaux, François Mesnard, Christophe Hano, Julie Lebas de Lacour, Eric Lainé, Laurine Garros, Thibaud Fidel, Samantha Drouet, Joël Doussot, Cédric Decourtil |
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| Přispěvatelé: | Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Institut National de la Recherche Agronomique (INRA)-Université d'Orléans (UO), SPF DIANA Pet Food Business, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Moléculaire et Stratégies Théranostiques - Clermont Auvergne (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Génie Enzymatique et Cellulaire (GEC), Université de Technologie de Compiègne (UTC)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), EA BIOPI Laboratoire de Phytotechnologie, Université de Picardie Jules Verne (UPJV), Diana Pet Food Business, Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie des Plantes et Innovation - UR UPJV 3900 (BIOPI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université de Picardie Jules Verne (UPJV)-Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Université d'Artois (UA)-Université de Liège-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Antioxidant Oxygen radical absorbance capacity flavonol medicine.medical_treatment [SDV]Life Sciences [q-bio] Pharmaceutical Science 01 natural sciences Antioxidants Analytical Chemistry chemistry.chemical_compound Flavonols Functional Food Gene Expression Regulation Plant Yeasts Drug Discovery Caffeic acid Food science Plant Proteins 2. Zero hunger chemistry.chemical_classification Lignan Vegetal Biology Molecular Structure activité antioxydante Gene Expression Regulation Developmental Hydroxycinnamic acid Secoisolariciresinol diglucoside Phytochemical Chemistry (miscellaneous) lignane Seeds potentiel antioxydant Molecular Medicine environment lignan hydroxycinnamic acid flax composé phénolique [SDV.CAN]Life Sciences [q-bio]/Cancer Biotechnologies acide cinnamique Article Lignans lcsh:QD241-441 03 medical and health sciences Phenols lcsh:Organic chemistry cultivar genetic seed medicine Humans Physical and Theoretical Chemistry ester hydroxycinnamique Plant Extracts Organic Chemistry linum usitatissimum Oxidative Stress 030104 developmental biology chemistry flavonoïde Lipid Peroxidation Biologie végétale 010606 plant biology & botany |
| Zdroj: | Molecules 10 (23), . (2018) Molecules Molecules, MDPI, 2018, 23 (10), ⟨10.3390/molecules23102636⟩ Molecules, Vol 23, Iss 10, p 2636 (2018) Molecules, 2018, 23 (10), ⟨10.3390/molecules23102636⟩ Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Volume 23 Issue 10 |
| ISSN: | 1420-3049 |
| Popis: | International audience; Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced. The importance of genetic parameters on the lignan accumulation was further confirmed by gene expression analysis monitored by RT-qPCR. The corresponding antioxidant activity of these flaxseed extracts was evaluated, both in vitro, using ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and iron chelating assays, as well as in vivo, by monitoring the impact of UV-induced oxidative stress on the lipid membrane peroxidation of yeast cells. Our results, both the in vitro and in vivo studies, confirm that flaxseed extracts are an effective protector against oxidative stress. The results point out that secoisolariciresinol diglucoside, caffeic acid glucoside, and p-coumaric acid glucoside are the main contributors to the antioxidant capacity. Considering the health benefits of these compounds, the present study demonstrates that the flaxseed cultivar type could greatly influence the phytochemical intakes and, therefore, the associated biological activities. We recommend that this crucial parameter be considered in epidemiological studies dealing with flaxseeds. |
| Databáze: | OpenAIRE |
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