Fighting bacterial infections—Future treatment options
| Autor: | Jenny Fernebro |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
medicine.medical_specialty Phage therapy medicine.drug_class Administration Topical medicine.medical_treatment Antimicrobial peptides Antibiotics Drug resistance Pharmacology Biology beta-Lactamases Mice Drug Delivery Systems Anti-Infective Agents Drug Resistance Bacterial medicine Animals Humans Bacteriophages Pharmacology (medical) Enzyme Inhibitors Intensive care medicine Beta-Lactamase Inhibitors Clinical Trials as Topic Bacteria Drug Synergism Bacterial Infections Potentiator Antibodies Bacterial Clinical trial Infectious Diseases Oncology Drug Design Bacterial Vaccines Chronic Disease Efflux beta-Lactamase Inhibitors Antimicrobial Cationic Peptides |
| Zdroj: | Drug Resistance Updates. 14:125-139 |
| ISSN: | 1368-7646 |
| DOI: | 10.1016/j.drup.2011.02.001 |
| Popis: | This review summarizes ongoing research aimed at finding novel drugs as alternatives to traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies are strategies that may yield drugs with high specificity and narrow spectra. Several candidates are currently being evaluated in clinical trials, mostly for topical applications, but so far, none have been approved for market authorization. Candidates based on antimicrobial peptides (natural, semisynthetic and synthetic) are also being tested in clinical trials, mostly for the topical treatment of chronic infections. An alternative to the development of new antibiotics is to find potentiators of traditional antibiotics; in this respect, beta-lactamase inhibitors are already in clinical use. Novel variants are under investigation as well as efflux pump inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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