In Vitro Activity of Ceftolozane-Tazobactam as Determined by Broth Dilution and Agar Diffusion Assays against Recent U.S. Escherichia coli Isolates from 2010 to 2011 Carrying CTX-M-Type Extended-Spectrum β-Lactamases
| Autor: | Susan L. Clugston, Mark Estabrook, Brianne Bussell, Karen Bush |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Tazobactam food.ingredient Penicillanic Acid Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology food Escherichia coli medicine Humans Agar Escherichia coli Infections Etest Broth microdilution CEFTOLOZANE/TAZOBACTAM Bacteriology United States In vitro Anti-Bacterial Agents Cephalosporins Ceftolozane medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 52:4049-4052 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | Ceftolozane MIC 50 /MIC 90 s were 4/8 μg/ml when tested against 26 CTX-M-14-type-producing isolates and 64/>64 μg/ml against 219 CTX-M-15-type-producing isolates. The addition of 4 μg/ml tazobactam lowered the ceftolozane MIC 50 /MIC 90 s to ≤0.25/0.5 μg/ml by broth microdilution and Etest. The zone diameters for the ceftolozane-tazobactam disks were 23 to 29 mm for 92.2% of the isolates. |
| Databáze: | OpenAIRE |
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