Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection
| Autor: | Macarena Pozo, Marc Claret |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Hypothalamus Homeòstasi Biology 03 medical and health sciences Endocrinology Diabetes mellitus medicine Diabetes Mellitus Glucose homeostasis Animals Homeostasis Humans Obesity Pancreas Hipotàlem Effector Skeletal muscle medicine.disease 030104 developmental biology medicine.anatomical_structure Glucose Signal transduction Neuroscience |
| Zdroj: | Trends in Endocrinology & Metabolism Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1879-3061 |
| Popis: | Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular homeostatic regions such as the hypothalamus, plays a crucial role in orchestrating such a highly integral response. We review here current understanding of how the hypothalamus senses glucose availability and participates in systemic glucose homeostasis. We provide an update of the relevant signaling pathways and neuronal subsets involved, as well as of the mechanisms modulating metabolic processes in peripheral tissues such as liver, skeletal muscle, fat, and especially the pancreas. We also discuss the relevance of these networks in human biology and prevalent metabolic conditions such as diabetes and obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect