OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance
| Autor: | Luis Miguel Martín-delosReyes, Jairo López-Gómez, Elena Moreno-Roldán, Pablo Redruello-Guerrero, Virginia Martínez-Ruiz, Antonio Jesús Láinez-Ramos-Bossini, Nicolás Francisco Fernández-Martínez, Mario Rivera-Izquierdo, Eladio Jiménez-Mejías, Carlos Rivera-Izquierdo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Carbapenem medicine.medical_specialty medicine.drug_class 030106 microbiology Cephalosporin Antibiotics antibiotic stewardship Review Biochemistry Microbiology carbapenem 03 medical and health sciences carbapenemase 0302 clinical medicine Antibiotic resistance Enterobacterales Environmental health medicine Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics OXA-48 outbreak business.industry multiresistant Public health lcsh:RM1-950 Outbreak biochemical phenomena metabolism and nutrition Carbapenemases lcsh:Therapeutics. Pharmacology Infectious Diseases Spain Antibiotic Stewardship business enterobacteria medicine.drug |
| Zdroj: | Antibiotics Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada instname Antibiotics, Vol 10, Iss 89, p 89 (2021) |
| ISSN: | 2079-6382 |
| Popis: | Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain. Chair of Teaching and Research in Family Medicine SEMERGEN-UGR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|