Impact of IL-22 and IL-22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women
| Autor: | Shiguo Liu, Jing Quan, Mengchun Liu, Xin Zhao, Aiping Chen, Yan Lin, Zhaoyuan Niu, Weiqing Song, Jing Li, Jingli Wang, Hongling Liu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult China Alpha (ethology) Single-nucleotide polymorphism Biochemistry Preeclampsia 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Pre-Eclampsia Pregnancy Risk Factors Genotype Medicine Humans Allele Molecular Biology Genotyping Alleles Polymorphism Genetic business.industry Interleukins Interleukin Cell Biology Odds ratio Receptors Interleukin medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Immunology Female business |
| Zdroj: | Journal of cellular biochemistry. 119(6) |
| ISSN: | 1097-4644 |
| Popis: | Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to investigate the association between polymorphisms of IL-22 and IL-22 receptor alpha 1 gene (IL-22RA1) and PE in Chinese Han population. Single nucleotide polymorphisms (SNPs) rs2227485 in IL-22 and rs3795299 in IL-22RA were genotyped by Taqman real-time PCR in 1071 PE patients and 1263 control subjects. Differences in genetic distribution were compared between two groups using the chi-square test. Significant differences were observed in genotypic and allelic frequencies of IL-22RA1 rs3795299 between healthy controls and PE patients (P < 0.001 by genotype; P = 0.001, odds ratio = 1.253, 95% confidence interval 1.103-1.424 by allele). There were also significant differences in genotypic and allelic frequencies of rs3795299 between late-onset/mild PE and control groups. In addition, we found obvious statistic difference for the allele of early-onset PE/the genotype of late-onset PE and control subgroups for IL-22 rs2227485. IL-22 rs2227485 and IL-22RA1 rs3795299 may be associated with the development of PE in Chinese Han population. However, further validation is required in other populations, as well as an evaluation of the association of other SNPs in IL-22 and IL-22RA1 with PE. |
| Databáze: | OpenAIRE |
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