Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors
| Autor: | Danielle G. Smith, Tapiwanashe Magwere, Susan A. Burchill |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Programmed cell death Antioxidant medicine.medical_treatment Antineoplastic Agents Bone Neoplasms Sarcoma Ewing medicine.disease_cause Antioxidants Neoplasms Detoxification Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) chemistry.chemical_classification Clinical Trials as Topic Reactive oxygen species Cell Death business.industry Cancer Oxidants medicine.disease Cell biology Oxidative Stress Oncology chemistry Toxicity Cancer cell Female Reactive Oxygen Species business Oxidation-Reduction Oxidative stress |
| Zdroj: | Expert Review of Anticancer Therapy. 11:229-249 |
| ISSN: | 1744-8328 1473-7140 |
| Popis: | Reactive oxygen species (ROS) are highly reactive by-products of energy production that can have detrimental as well as beneficial effects. Unchecked, high levels of ROS result in an imbalance of cellular redox state and oxidative stress. High levels of ROS have been detected in most cancers, where they promote tumor development and progression. Many anticancer agents work by further increasing cellular levels of ROS, to overcome the antioxidant detoxification capacity of the cancer cell and induce cell death. However, adaptation of the level of cellular antioxidants can lead to drug resistance. The challenge for the design of effective cancer therapeutics exploiting oxidative stress is to tip the cellular redox balance to induce ROS-dependent cell death but without increasing the antioxidant activity of the cancer cell or inducing toxicity in normal cells. |
| Databáze: | OpenAIRE |
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