Coronary restenosis: Evaluation of a restenosis injury index in a swine model
| Autor: | Patrice Paiement, Tack Ki Leung, Raoul Bonan, Doria Scortichini, Marie-Josée Cloutier |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Intimal hyperplasia Swine Coronary restenosis Coronary Disease Balloon Restenosis Recurrence Internal medicine medicine Animals Angioplasty Balloon Coronary Hyperplasia business.industry Vascular disease Internal elastic lamina medicine.disease Coronary Vessels Coronary arteries Disease Models Animal medicine.anatomical_structure Cardiology Swine Miniature Female Radiology Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | American Heart Journal. 126:1334-1340 |
| ISSN: | 0002-8703 |
| Popis: | To investigate the mechanisms of restenosis and detect useful interventions to prevent it, reliable quantitative measurements must be evaluated. Coronary arteries of domestic and minipigs (n = 18) were mechanically injured by balloon overstretching and killed at different intervals (2 to 25 weeks) after quantitative angiographic analysis. Morphometric measurements evaluated intimal hyperplasia at 0.59 ± 0.42 mm without relation to artery size or balloon/artery ratio. Intimal hyperplasia, expressed as the ratio of neointimal area to total wall area (A), is directly related to the injury, assessed by the ratio of internal elastic lamina (IEL) fracture length to IEL circumference (B), r = 0.84, p = 0.002. Restenosis injury index, defined as A B , provides a useful tool for the quantitative assessment of future angioplasty-related restenosis interventions. |
| Databáze: | OpenAIRE |
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