Does IGF-1 play a role in the etiopathogenesis of non-functioning adrenocortical adenoma?
| Autor: | Cigdem Tura Bahadir, Gulcin Cengiz Ecemis, Hulusi Atmaca |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Waist Non-functioning adrenocortical adenoma Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Adrenal incidentaloma Gastroenterology Adrenocortical adenoma Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Acromegaly medicine Humans Insulin Insulin-Like Growth Factor I education education.field_of_study medicine.diagnostic_test business.industry Human Growth Hormone Magnetic resonance imaging Middle Aged medicine.disease Adrenal Cortex Neoplasms Adrenocortical Adenoma IGF-1 Homeostatic model assessment Female Insulin Resistance business Body mass index |
| Zdroj: | Journal of endocrinological investigation. 41(11) |
| ISSN: | 1720-8386 |
| Popis: | WOS: 000447811100009 PubMed: 29542030 PurposeThe aim of this study was to investigate the possible association of insulin-like growth factor-1 (IGF-1) with the pathogenesis of non-functioning adrenocortical adenomas (NFAs).MethodsThis study included 50 female patients (mean age 54years) with NFAs, 55 patients (mean age 48years; 20 male, 35 female) with acromegaly and 38 female control subjects (mean age 58years). Body mass index (BMI) and waist circumference (WC) of the subjects were recorded and blood samples for IGF-1 were taken. Insulin resistance was calculated using the homeostatic model assessment (HOMA) score. Since most of the acromegaly patients had been using medicine that could have effected insulin resistance, HOMA scores were calculated only in patients with NFAs and the controls. Computerized tomography or magnetic resonance imaging was taken of the acromegalics and controls to detect adrenal mass frequency.ResultsThe mean age was similar among the groups. As expected, the serum IGF-1 levels were significantly higher in patients with acromegaly than in patients with NFAs and the controls (p |
| Databáze: | OpenAIRE |
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