Unexpected Oxidative Ring Opening of Electron-Rich 3-Aminobenzofurans into α-Ketoimines Derivatives
| Autor: | Nour-Eddine Ghermani, Olivier Provot, Ilhem Khelifi, Guangkuan Zhao, Mouad Alami |
|---|---|
| Přispěvatelé: | Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
radical
ketoimine [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Organic Chemistry benzofuran Oxidative phosphorylation 010402 general chemistry Ring (chemistry) 01 natural sciences Combinatorial chemistry Toluene 0104 chemical sciences chemistry.chemical_compound chemistry ring-opening NaOtBu Benzofuran |
| Zdroj: | Journal of Organic Chemistry Journal of Organic Chemistry, American Chemical Society, 2019, 84 (4), pp.1725-1733. ⟨10.1021/acs.joc.8b01685⟩ |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | International audience; An unexpected ring opening of 3-aminobenzofurans promoted by NaOtBu in hot toluene, leading to a variety of α-ketoimines, is described. In the presence of 3-iodobenzofurans, NaOtBu mediates the 3-aminobenzofurans ring opening via a possible radical pathway without the help of any external radical sources. |
| Databáze: | OpenAIRE |
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