The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients
| Autor: | Jacques Merrer, Philippe Rousselot, Marie-Paule Fernandez-Gerlinger, Anne-Sophie Jannot, Sophie Rigaudeau, Sylvie Castaigne, Hassan Farhat, Juliette Lambert, François Mignon, Odile Eloy |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Neutropenia Epidemiology 030106 microbiology Population Air Microbiology 030501 epidemiology Aspergillosis law.invention 03 medical and health sciences law Internal medicine medicine Humans education Decontamination Aged Retrospective Studies Invasive Pulmonary Aspergillosis Cross Infection education.field_of_study business.industry Incidence (epidemiology) Retrospective cohort study Odds ratio Middle Aged medicine.disease Intensive care unit Exact test Infectious Diseases Hematologic Neoplasms Female 0305 other medical science business |
| Zdroj: | Infection Control & Hospital Epidemiology. 37:845-851 |
| ISSN: | 1559-6834 0899-823X |
| DOI: | 10.1017/ice.2016.81 |
| Popis: | OBJECTIVEInvasive aspergillosis (IA) is a rare but severe infection caused by Aspergillus spp. that often develops in immunocompromised patients. Lethality remains high in this population. Therefore, preventive strategies are of key importance. The impact of a mobile air decontamination system (Plasmair, AirInSpace, Montigny-le-Bretonneux, France) on the incidence of IA in neutropenic patients was evaluated in this study.DESIGNRetrospective cohort studyMETHODSPatients with chemotherapy-induced neutropenia lasting 7 days or more were included over a 2-year period. Cases of IA were confirmed using the revised European Organization for Research and Treatment of Cancer (EORTC) criteria. We took advantage of a partial installation of Plasmair systems in the hematology intensive care unit during this period to compare patients treated in Plasmair-equipped versus non-equipped rooms. Patients were assigned to Plasmair-equipped or non-equipped rooms depending only on bed availability. Differences in IA incidence in both groups were compared using Fisher’s exact test, and a multivariate analysis was performed to take into account potential confounding factors.RESULTSData from 156 evaluable patients were available. Both groups were homogenous in terms of age, gender, hematological diagnosis, duration of neutropenia, and prophylaxis. A total of 11 cases of probable IA were diagnosed: 10 in patients in non-equipped rooms and only 1 patient in a Plasmair-equipped room. The odds of developing IA were much lower for patients hospitalized in Plasmair-equipped rooms than for patients in non-equipped rooms (P=.02; odds ratio [OR] =0.11; 95% confidence interval [CI], 0.00–0.84).CONCLUSIONIn this study, Plasmair demonstrated a major impact in reducing the incidence of IA in neutropenic patients with hematologic malignancies.Infect Control Hosp Epidemiol 2016;37:845–851 |
| Databáze: | OpenAIRE |
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