Orofacial neuropathic pain reduces spontaneous burrowing behavior in rats
| Autor: | Kristof Deseure, Guy Hans |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Experimental and Cognitive Psychology Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience Infraorbital nerve 0302 clinical medicine Facial Pain Physical Stimulation parasitic diseases medicine Animals Psychology Tibial nerve Ligation Biology Pain Measurement business.industry fungi medicine.disease musculoskeletal system Grooming Rats Disease Models Animal Hyperalgesia 030220 oncology & carcinogenesis Anesthesia Spinal nerve Neuropathic pain Peripheral nerve injury Exploratory Behavior Neuralgia Sciatic nerve Human medicine medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Physiology and behavior |
| ISSN: | 0031-9384 |
| Popis: | It was recently reported that spontaneous burrowing behavior is decreased after tibial nerve transection, spinal nerve transection and partial sciatic nerve ligation. It was proposed that spontaneous burrowing could be used as a measure of the impact of neuropathic pain after peripheral nerve injury. It has remained unclear whether the reduction in burrowing behavior is caused directly by pain or hypersensitivity in the affected limbs, making it more difficult to perform burrowing, or by a pain induced decrease in the general wellbeing, thus reducing the motivation to burrow. We studied burrowing behavior after infraorbital nerve injury, a model of orofacial neuropathic pain that does not affect the limbs. Burrowing behavior was significantly reduced after infraorbital nerve injury. Isolated face grooming and responsiveness to mechanical von Frey stimulation of the infraorbital nerve territory were significantly increased after infraorbital nerve injury, indicative, respectively, of spontaneous pain and mechanical allodynia. It is concluded that spontaneous burrowing may provide a measure of the global impact of pain on the animal's wellbeing after peripheral nerve injury and incorporation of this behavioral assay in preclinical drug testing may improve the predictive validity of currently used pain models. |
| Databáze: | OpenAIRE |
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