Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors

Autor:	Yu-Gui Si, Tangzhi Zhang, Susan R. George, Philip Seeman, Anna W. Sromek, John L. Neumeyer
Rok vydání:	2011
Předmět:	Catechol Organic Chemistry Aporphines Pharmacology Biochemistry Combinatorial chemistry chemistry.chemical_compound chemistry Dopamine receptor Dopamine Dopamine receptor D2 Drug Discovery medicine Aporphine Receptor Selectivity medicine.drug
Zdroj:	ACS Medicinal Chemistry Letters. 2:189-194
ISSN:	1948-5875
DOI:	10.1021/ml1001689
Popis:	The 2-fluoroalkoxy substituted catechol-aporphines 6, 8a-f and 11-monohydroxyaporphines 11a-e were synthesized and found to have high in vitro affinity and selectivity for the dopamine D(2) receptors. The catechol aporphines, 8b and 8d, and the monohydroxy aporphines, 11a-d, were identified as candidates for development as potential PET ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db43736e1f1f187ab7665f93e5bab5 https://doi.org/10.1021/ml1001689 Zobrazit plný text záznamu