Liver Transplantation (LT) for Cryptogenic Cirrhosis (CC) and Nonalcoholic Steatohepatitis (NASH) Cirrhosis
| Autor: | Zobair M. Younossi, Cameron T. Locklear, Maria Stepanova, Alita Mishra, Madeline Erario, Pegah Golabi, Ira M. Jacobson, Issah Younossi, Zachary Goodman, Chapy Venkatesan, Haley Bush, Gregory Trimble |
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| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male Nonalcoholic steatohepatitis cryptogenic cirrhosis Cirrhosis medicine.medical_treatment Comorbidity Liver transplantation Gastroenterology 0302 clinical medicine Non-alcoholic Fatty Liver Disease Risk Factors Metabolic Syndrome diabetes Age Factors NASH General Medicine Middle Aged transplant registry 030220 oncology & carcinogenesis Cryptogenic cirrhosis Hepatocellular carcinoma ComputingMethodologies_DOCUMENTANDTEXTPROCESSING outcome Female 030211 gastroenterology & hepatology Research Article Adult medicine.medical_specialty Waiting Lists Observational Study digestive system 03 medical and health sciences Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Aged business.industry MELD score nutritional and metabolic diseases medicine.disease mortality United States digestive system diseases Liver Transplantation Metabolic syndrome business |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000011518 |
| Popis: | Supplemental Digital Content is available in the text Nonalcoholic steatohepatitis (NASH)-related cirrhosis and cryptogenic cirrhosis (CC) have become leading indications for liver transplantation (LT) in the US. Our aim was to compare the trends, clinical presentation, and outcomes for transplant candidates with NASH and CC. The Scientific Registry of Transplant Recipients (1994–2016) was used to select adult LT candidates and recipients with primary diagnoses of NASH and CC without hepatocellular carcinoma. Two lakh twenty-three thousand three hundred ninety-one LT candidates were listed between 1994 and 2016. Of these, 16,214 (7.3%) were listed for CC and 11,598 (5.2%) for NASH. Before 2004, NASH was seldom coded for an indication for LT, but became more common after 2009. Averaged across the study period, CC candidates compared with NASH candidates were younger and had fewer conditions of metabolic syndrome (MS). CC patients were more likely to have MS components in comparison to candidates with other chronic liver diseases (CLDs) (all P |
| Databáze: | OpenAIRE |
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