Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders
| Autor: | Cvetka Bačar Bole, Mitja Pišlar, Rok Tavcar, Metka Šen, Aleš Mrhar |
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| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.medical_treatment Pharmaceutical Science 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine Psychiatric hospital 030212 general & internal medicine Medical prescription Antipsychotic Prospective cohort study Psychiatry Pharmaceutical industry Pharmacology business.industry switching antipsychotics causes General Medicine medicine.disease 030227 psychiatry schizophrenia Clinical research Schizophrenia strategies Observational study HD9665-9675 business |
| Zdroj: | Acta Pharmaceutica, Vol 67, Iss 1, Pp 99-112 (2017) |
| ISSN: | 1846-9558 |
| DOI: | 10.1515/acph-2017-0001 |
| Popis: | The study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsychotics and switching strategies were analyzed. Analyzing a total of 3954 prescriptions, the collected data confirmed that treatment strategies in this psychiatric hospital are very complex. It was found that 37 percent of inpatients had at least one switch. Moreover, switches that included three or more antipsychotics were detected. The most common causes for switching antipsychotics were adverse reactions and inefficacy or lack of efficacy. Among switching options, abrupt switch was recorded several times. As some patients are receiving several antipsychotics at the same time, it is possible that unusual switching occurs in clinical practice. It seems that the choice of switching strategy is also affected by the cause and urgency for switching an antipsychotic. |
| Databáze: | OpenAIRE |
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