Association between the intrarenal renin-angiotensin system and renal injury in chronic kidney disease of dogs and cats
| Autor: | Sawane Mitani, Osamu Yamato, Kazuyuki Taniguchi, Akira Yabuki |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty CATS General Veterinary business.industry Angiotensin II Glomerulosclerosis Glomerular Hypertrophy medicine.disease Cat Diseases Kidney Interstitial cell Renin-Angiotensin System Dogs Renal physiology Renin–angiotensin system Renin Cats Medicine Animals Dog Diseases Renal Insufficiency Chronic business Kidney disease |
| Zdroj: | The Journal of veterinary medical science. 75(2) |
| ISSN: | 1347-7439 |
| Popis: | The association of renin and angiotensin II, which are potent components of the renin-angiotensin system, with the severity of chronic renal disease was investigated immunohistochemically in dogs and cats. Immunoreactivities of renin and angiotensin II were evaluated quantitatively, and their correlations with the degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration and interstitial fibrosis were statistically analyzed. Immunoreactivities for renin were detected in afferent arteries in both dogs and cats. The score of renin-positive signals showed no correlation with plasma creatinine concentration or any of the histopathological parameters, except for the diameter of glomeruli in dogs. Immunoreactivities for angiotensin II were detected in tubules (primarily proximal tubules) and interstitial mononuclear cells in both dogs and cats. The score of tubular angiotensin II correlated with glomerulosclerosis and cell infiltration in cats but not in dogs. The score of interstitial angiotensin II correlated with plasma creatinine concentration, glomerulosclerosis, cell infiltration and fibrosis in dogs and with glomerulosclerosis and cell infiltration in cats. In conclusion, the results of the study suggest that intrarenal renin-angiotensin system is correlated with the severity of kidney disease, with the underlying mechanism differing between dogs and cats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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