Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study
| Autor: | Augustin Scalbert, Marjukka Kolehmainen, Pekka Keski-Rahkonen, Valerie Micard, Kaisa S. Poutanen, Jussi Pihlajamäki, Marc J. Gunter, Natalia Rosa-Sibakov, Jenna Jokkala, Hannu Mykkänen, Pirkka V. Kirjavainen, Jenni Lappi, Kati Hanhineva |
|---|---|
| Přispěvatelé: | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Eastern Finland, Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Kuopio University Hospital, Natl Inst Hlth & Welf, Partenaires INRAE, VTT Technical Research Centre of Finland (VTT), Int Agcy Res Canc, Lyon, France, Academy of Finland, Biocenter Finland, International Agency for Research on Cancer, Region Ile-de-France Region Occitanie, Association Franco-Finlandaise pour la Recherche Scientifique et Technique (AFFRST), French National Education Ministry, Finnish Funding Agency for Technology & Innovation (TEKES), Raisio plc Research Foundation, Nordic Centre of Excellence (SYSDIET) : 070014, Nordic Centre of Excellence (HELGA) : 070015 Agropolis Fondation, Organisation de Cooperation et de Developpement Economiques (OCDE) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Dietary Fiber
Male 0301 basic medicine Taurine [SDV.BIO]Life Sciences [q-bio]/Biotechnology Colon Diet therapy wholegrain Metabolite 5-HT Medicine (miscellaneous) 030209 endocrinology & metabolism plasmalogen Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alkylresorcinol SDG 3 - Good Health and Well-being dietary intervention Animals Humans [SDV.BV]Life Sciences [q-bio]/Vegetal Biology Food science Triticum 5-HT receptor Aged 2. Zero hunger Whole Grains glycerophosphocholine 030109 nutrition & dietetics Nutrition and Dietetics Bran Chemistry Secale digestive oral and skin physiology food and beverages Bread Middle Aged Crossover study metabolomics serotonin Mice Inbred C57BL rye Female Serotonin alkylresorcinol taurine |
| Zdroj: | American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 2019, 109 (6), pp.1630-1639. ⟨10.1093/ajcn/nqy394⟩ Keski-Rahkonen, P, Kolehmainen, M, Lappi, J, Micard, V, Jokkala, J, Rosa-Sibakov, N, Pihlajamäki, J, Kirjavainen, P V, Mykkänen, H, Poutanen, K, Gunter, M J, Scalbert, A & Hanhineva, K 2019, ' Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye : An untargeted metabolomics study ', The American journal of clinical nutrition, vol. 109, no. 6, pp. 1630-1639 . https://doi.org/10.1093/ajcn/nqy394 |
| ISSN: | 0002-9165 |
| Popis: | BACKGROUND: Wholegrain consumption has been associated with beneficial health effects including reduction of diabetes and cancer risk; however, the underlying mechanisms are not fully understood.OBJECTIVE: The aim of this study was to characterize the effects of wholegrain rye intake on circulating metabolites in a human intervention study using untargeted metabolomics.METHODS: The intervention consisted of 2 successive 4-wk periods in a randomized crossover design, where 15 adults consumed wholegrain rye bread (WGR) or white wheat bread enriched with fermented rye bran (WW+RB), following a 4-wk rye-free period with white wheat bread (WW). Fasting plasma samples were collected at the end of each period and analyzed using liquid chromatography-mass spectrometry. Metabolic profiles were compared to identify compounds discriminating WGR from the WW+RB and WW periods. Because peripheral serotonin is produced mainly in the gut, a hypothesis of its altered biosynthesis as a response to increased cereal fiber intake was tested by measuring intestinal serotonin of mice fed for 9 wk on a high-fat diet supplemented with different sources of fiber (rye bran flour, ground wheat aleurone, or powdered cellulose).RESULTS: Five endogenous metabolites and 15 rye phytochemicals associated with WGR intake were identified. Plasma concentrations of serotonin, taurine, and glycerophosphocholine were significantly lower after the WGR than WW period (Q < 0.05). Concentrations of 2 phosphatidylethanolamine plasmalogens, PE(18:2/P-18:0) and PE(18:2/P-16:0), were lower after the WGR period than the WW+RB period (Q < 0.05). The concentration of serotonin was significantly lower in the colonic tissue of mice that consumed rye bran or wheat aleurone compared with cellulose (P < 0.001).CONCLUSIONS: Wholegrain rye intake decreases plasma serotonin in healthy adults when compared with refined wheat. Intake of rye bran and wheat aleurone decreases colonic serotonin in mice. These results suggest that peripheral serotonin could be a potential link between wholegrain consumption and its associated health effects.Data used in the study were derived from a trial registered at www.clinicaltrials.gov as NCT03550365. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|