Effect of Certain Polypeptides on the Biological Activities of Measles Virus
| Autor: | Erling Norrby, Hans Sievertsson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Erythrocytes
Lysis Tripeptide Hemolysis Measles virus Hemoglobins chemistry.chemical_compound Non-competitive inhibition Chlorocebus aethiops Aromatic amino acids medicine Animals Pharmacology (medical) Vero Cells Pharmacology Virulence biology Tetrapeptide Hemolysin Articles biology.organism_classification medicine.disease Infectious Diseases Biochemistry chemistry Peptides Measles |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 5:426-430 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.5.4.426 |
| Popis: | The effect of a selected tripeptide, Z- d -Phe-Phe-Arg(NO 2 ) (SV-4814) on the kinetics of lysis of green monkey erythrocytes by measles virus hemolysin suggested conditions of competitive inhibition. SV-4814 prevented not only hemoglobin release, but also the preceding leakage of K + through the cell membrane. The capacity of 12 different dipeptides, 6 tripeptides, including SV-4814, and 4 tetrapeptides to inhibit measles virus-specific hemolysis and infectivity was analyzed. Tri- and tetrapeptides were more active than dipeptides. The presence of aromatic amino acids and a free carboxyl terminal appeared to be a prerequisite for inhibitory activity. Two compounds, one tripeptide (Z-Phe- d -Phe- d -Tyr) and one tetrapeptide [Z- d -Phe-Arg(NO 2 )- d -Met], carried an inhibitory activity, which was about two times higher than that of SV-4814. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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