Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females

Autor: Suzanne Vrshek-Schallhorn, Bradley M. Avery
Rok vydání: 2016
Předmět:
Male
Serotonin
medicine.medical_specialty
Adolescent
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Physiology
Affect (psychology)
Polymorphism
Single Nucleotide
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Endocrinology
Risk Factors
Surveys and Questionnaires
Internal medicine
Receptor
Serotonin
5-HT2C
medicine
Trier social stress test
Humans
Genetic Predisposition to Disease
Young adult
Saliva
Reactivity (psychology)
Alleles
Biological Psychiatry
Depression (differential diagnoses)
Depressive Disorder
Major
Depression
Endocrine and Autonomic Systems
Case-control study
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Case-Control Studies
Major depressive disorder
Female
Psychology
Stress
Psychological
030217 neurology & neurosurgery
medicine.drug
Zdroj: Psychoneuroendocrinology. 70:134-141
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2015.12.023
Popis: Genetic influences on stress reactivity may provide insight into depression risk mechanisms. The C-allele of rs6318, a putatively functional polymorphism located within the HTR2C gene, has been reported to predict greater cortisol and negative affective reactivity to lab-induced stress. However, the potential moderating effect of sex has not been examined despite X-linkage of HTR2C. We hypothesized that sex moderates the effect of rs6318 on cortisol and affective reactivity to lab-induced stress, with males showing stronger effects.Non-depressed young adults (N=112; 39 female) screened via clinical interview provided a DNA sample and completed either a negative evaluative Trier Social Stress Test, or a non-evaluative control protocol. Salivary cortisol and self-reported affect were assessed at four timepoints.Contrary to hypotheses, C-carriers showed blunted rather than exaggerated cortisol responses to lab-induced stress in multilevel models (b=0.467, p0.001), which persisted when covarying subclinical depressive symptoms. This effect was not moderated by sex (b=0.174, p=0.421), and remained significant when examining females (b=0.362, p=0.013) and males (b=0.537, p0.001) separately. C-carriers also exhibited marginally greater reactivity in negative self-focused affect in response to stress than non-carriers when covarying subclinical depressive symptoms (b=-0.360, p=0.067), and exhibited higher levels of subclinical depressive symptoms than non-carriers (F=6.463, p=0.012).Results support a role for the rs6318 C-allele in dysregulated stress responding, and suggest that the C-allele may contribute to risk for depression.
Databáze: OpenAIRE
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