RETRACTED: Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2
| Autor: | Hany A. Elkattawy, Mohamed El-Sherbiny, Mona Qushawy, Eman Said, Eslam K. Fahmy, Nehal M. Elsherbiny |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
NF-E2-Related Factor 2 medicine.medical_treatment Tranilast Interleukin-1beta Metal Nanoparticles Pharmacology Toxicology medicine.disease_cause Proinflammatory cytokine Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Creatine Kinase BB Form NLR Family Pyrin Domain-Containing 3 Protein medicine Animals ortho-Aminobenzoates Cerebrum Creatine Kinase 030304 developmental biology 0303 health sciences Interleukin-6 General Neuroscience Caspase 1 Silver Compounds Glutathione Mast cell Rats Toll-Like Receptor 4 Oxidative Stress Neuroprotective Agents medicine.anatomical_structure chemistry Toxicity TLR4 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | NeuroToxicology. 82:167-176 |
| ISSN: | 0161-813X |
| DOI: | 10.1016/j.neuro.2020.12.008 |
| Popis: | Silver nanoparticles (AgNPs) are widely applied in various aspects of life. However, recent studies reported their potential toxicity both on environment and human health. The present study aimed to unravel the underlying molecular mechanisms involved in AgNPs-induced brain toxicity. Moreover, chemopreventive effect of tranilast, an analogue of tryptophan metabolite and a mast cell membrane stabilizer was evaluated. Thirty Sprague Dawley rats were enrolled equally into Normal control group, AgNPs-intoxicated group (50 mg/kg, 3 times/week) and tranilast (300 mg/kg, 3 times/week)+AgNPs group. AgNPs administration triggered brain oxidative stress as depicted by reduced Nrf-2 expression, decreased TAC and GSH as well as upregulated brain lipid peroxidation. The apparent brain oxidative damage was accompanied by elevated levels of inflammatory cytokines (IL-1β, IL-6 and TNF-α). Moreover, brain levels of TLR4, NLRP3 and caspase-1 were up-regulated. Additionally, histological study indicated marked cellular injury in cerebrum and cerebellum specimens. This was concomitant with elevated serum CK activity and CK-BB level. On the other hand, tanilast administration remarkably alleviated AgNPs-induced brain toxicity. The present study shed the light on implication of TLR4/NLRP3 axis and NrF2 in AgNPs-induced brain toxicity. In addition, it explored the potential protective effect of tranilast on AgNPs-induced brain injury via antioxidant and anti-inflammatory efficacies. |
| Databáze: | OpenAIRE |
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