Analysis of Mesencephalic Astrocyte-derived Neurotrophic Factor in Multiple Myeloma
| Autor: | Antoine Galmiche, Christophe Louandre, Yves-Edouard Herpe, Chloé Sauzay, Amandine Dernoncourt, Cathy Gomila, Pierre Duhaut, Jean Schmidt, V. Salle, Zuzana Saidak |
|---|---|
| Přispěvatelé: | CHU Amiens-Picardie, Centre Eugène Marquis (CRLCC), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Interne [CHU Amiens-Picardie], Réseau d'Epidémiologie Clinique International Francophone [Amiens] (RECIF Amiens), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de dermatologie [CHU d'Amiens-Picardie], Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Biobanque de Picardie [CHU Amiens - Hôpital Sud] |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Cancer Research [SDV]Life Sciences [q-bio] Monoclonal Gammopathy of Undetermined Significance Pathogenesis Young Adult Downregulation and upregulation Neurotrophic factors Cell Line Tumor Medicine cancer Humans Computer Simulation Nerve Growth Factors Multiple myeloma Aged Retrospective Studies Aged 80 and over business.industry General Medicine unfolded protein response Middle Aged medicine.disease Up-Regulation Gene Expression Regulation Neoplastic mesencephalic astrocyte-derived neurotrophic factor medicine.anatomical_structure Oncology Cell culture Case-Control Studies Cancer research Biomarker (medicine) biomarker business Multiple Myeloma Monoclonal gammopathy of undetermined significance Astrocyte |
| Zdroj: | Anticancer Research Anticancer Research, 2021, 41 (9), pp.4305-4312. ⟨10.21873/anticanres.15235⟩ |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | International audience; Background/Aim: Multiple myeloma (MM) is characterized by high production of immunoglobulins resulting in a constant source of endoplasmic reticulum (ER)-stress. Mesencephalic astrocyte-derived neurotrophic factor (MANF) was identified as a possible circulating biomarker that could help in monitoring ER-stress mediated diseases. Materials and Methods: To assess the relevance of MANF in MM, we performed in silico and in vitro analysis in malignant cell lines including the myeloma cell line RPMI 8226. Serum MANF concentration was compared between healthy subjects (n=60), patients with MM (n=68), or those with monoclonal gammopathy of undetermined significance (MGUS) (n=73). Results: MANF mRNA expression was upregulated in the RPMI 8226 cell line, and higher secretion of MANF was measured in RPMI 8226 supernatant. Serum MANF levels were not significantly different between MM or MGUS patients and those in age-and sex-matched healthy controls. Conclusion: MANF was not validated as a biomarker of interest in MM patients. Its potential implication in myeloma pathogenesis should be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|