Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers
Autor: | Vibeke Horstmann, Hans Welinder, Staffan Skerfving, Jörn Nielsen |
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Rok vydání: | 1992 |
Předmět: |
Adult
Male medicine.medical_specialty Allergy Adolescent Vital Capacity Air Pollutants Occupational Immunoglobulin E Work related Gastroenterology Drug Hypersensitivity Forced Expiratory Volume Internal medicine Methyltetrahydrophthalic anhydride Humans Medicine Nose Aged Skin Tests Asthma biology Epoxy Resins business.industry Smoking Respiratory disease Public Health Environmental and Occupational Health Middle Aged medicine.disease Occupational Diseases medicine.anatomical_structure Phthalic Anhydrides Toxicity Immunology biology.protein Female business Research Article |
Zdroj: | Occupational and Environmental Medicine. 49:769-775 |
ISSN: | 1351-0711 |
Popis: | One hundred and forty four current and 26 former workers in a plant producing barrels for rocket guns from an epoxy resin containing methyltetrahydrophthalic anhydride (MTHPA; time weighted average air concentration up to 150 micrograms/m3) were studied. They showed higher frequencies of work related symptoms from the eyes (31 v 0%; p < 0.001), nose (53 v 9%; p < 0.001), pharynx (26 v 6%; p < 0.01), and asthma (11 v 0%; p < 0.05) than 33 controls. Also they had higher rates of positive skin prick test to a conjugate of MTHPA and human serum albumin (16 v 0%; p < 0.01), and more had specific IgE and IgG serum antibodies (18 v 0%; p < 0.01 and 12 v 0%; p < 0.05 respectively). There were statistically significant exposure-response relations between exposure and symptoms from eyes and upper airways, dry cough, positive skin prick test, and specific IgE and IgG antibodies. There was a non-significant difference in reaction to metacholine between exposed workers and non-smoking controls. In workers with and without specific IgE antibodies, differences existed in frequency of nasal secretion (54 v 23%; p < 0.05) and dry cough (38 v 12%; p < 0.05). Workers with specific IgG had more dry cough (38 v 12%; p < 0.05), but less symptoms of non-specific bronchial hyperreactivity (0 v 26%; p < 0.05). Atopic workers sneezed more than non-atopic workers (65 v 30%; p < 0.01). In a prospective study five sensitised workers who left the factory became less reactive to metacholine, and became symptom free. In 41 workers who stayed, there was no improvement, despite a 10-fold reduction in exposure. The results show the extreme sensitising properties of MTHPA. |
Databáze: | OpenAIRE |
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