Cell-selective proteomics for biological discovery
| Autor: | Shannon E. Stone, David A. Tirrell, Weslee S. Glenn, Graham D Hamblin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Proteomics Proteomics methods Proteome Cell Biology 010402 general chemistry Protein labeling 01 natural sciences Biochemistry Mass Spectrometry Article Analytical Chemistry Cell Line 03 medical and health sciences medicine Animals Humans Bacteria Extramural Proteins 0104 chemical sciences Cell biology 030104 developmental biology medicine.anatomical_structure Protein Biosynthesis |
| Zdroj: | Current opinion in chemical biology. 36 |
| ISSN: | 1879-0402 |
| Popis: | Cells alter the proteome to respond to environmental and developmental cues. Global analysis of proteomic responses is of limited value in heterogeneous environments, where there is no ‘average’ cell. Advances in sequencing, protein labeling, mass spectrometry, and data analysis have fueled recent progress in the investigation of specific subpopulations of cells in complex systems. Here we highlight recently developed chemical tools that enable cell-selective proteomic analysis of complex biological systems, from bacterial pathogens to whole animals. |
| Databáze: | OpenAIRE |
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