Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires
| Autor: | Petya Dimitrova, A. Terzieva, Violeta Dimitrova, Silvina Zapryanova, Tanya Dimova, Iana Hristova, Ivaylo Vangelov, Lyubomir Djerov |
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| Přispěvatelé: | Dimova, Tanya, Tanya Dimova, Violeta Dimitrova |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
T-Lymphocytes Population TCR repertoire diversity Biology Lymphocyte Activation Catalysis Article Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Fetus Pregnancy delta T-cell effectors human pregnancy medicine Immune Tolerance Humans Physical and Theoretical Chemistry education Molecular Biology lcsh:QH301-705.5 Spectroscopy Tissue homeostasis education.field_of_study Organic Chemistry T-cell receptor Decidua gamma/delta T-cell effectors Receptors Antigen T-Cell gamma-delta General Medicine medicine.disease Phenotype Computer Science Applications 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Immunology Female gamma 030215 immunology decidua |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 3, p 687 (2019) International Journal of Molecular Sciences Volume 20 Issue 3 |
| ISSN: | 1422-0067 |
| Popis: | Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of harmful responses towards the fetus and ability to fight infections. TCR γδ cells have been implicated in the responses in infectious diseases, in the regulation of immune responses, and in tissue homeostasis and repair. The variety of functions makes γδ T cells a particularly interesting population during pregnancy. In this study, we investigated the proportion, phenotype and TCR γ and δ repertoires of γδ T cells at the maternal⁻fetal interface and in the blood of pregnant women using FACS, immunohistochemistry and spectratyping. We found an enrichment of activated and terminally differentiated pro-inflammatory γδ T-cell effectors with specific location in the human decidua during early pregnancy, while no significant changes in their counterparts in the blood of pregnant women were observed. Our spectratyping data revealed polyclonal CDR3 repertoires of the δ1, δ2 and δ3 chains and γ2, γ3, γ4 and γ5 chains and oligoclonal and highly restricted CDR3γ9 repertoire of γδ T cells in the decidua and blood of pregnant women. Early pregnancy induces recruitment of differentiated pro-inflammatory γδ T-cell effectors with diverse TCR repertoires at the maternal⁻fetal interface. |
| Databáze: | OpenAIRE |
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