Association of lubricin concentration in synovial fluid and clinical status of osteoarthritic knee
| Autor: | Nobuo Terabayashi, Haruhiko Akiyama, Hiroyasu Ogawa, Kenji Kawashima, Kentaro Takeuchi, Kazu Matsumoto |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Knee function Adult Male medicine.medical_specialty Adolescent Knee Joint Osteoarthritis Gastroenterology Joint laxity 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Synovial Fluid medicine Synovial fluid Humans Clinical significance Osteoarthritic knee Range of Motion Articular Aged Glycoproteins Aged 80 and over 030222 orthopedics business.industry Middle Aged Osteoarthritis Knee musculoskeletal system medicine.disease Surgery 030104 developmental biology Knee surgery Case-Control Studies Female Range of motion business Biomarkers |
| Zdroj: | Modern rheumatology. 27(3) |
| ISSN: | 1439-7609 |
| Popis: | Although lubricin plays a role in controlling inflammation and pain as well as being a mechanical lubricant, clinical relevance of lubricin concentration in synovial fluid (SF) is unknown. The purpose was to determine whether lubricin concentration in SF is associated with the clinical status of the knee.SF was obtained from 61 knee joints from patients who underwent any knee surgery with several stages of knee osteoarthritis. Lubricin/PRG4 concentration in SF was measured by enzyme-linked immunosorbent assay (ELISA). Clinical evaluations of the knee by the Kellgren and Lawrence (K-L) system, Knee Society Score (KSS), and the range of knee motion, and assessment of joint laxity were performed. Association of lubricin concentration in SF and these clinical factors was statistically analyzed.There was no significant correlation between lubricin concentration in SF and age, sex, K-L grade, or KSS. However, lubricin concentration was significantly correlated with anteroposterior laxity (R = 0.50, p 0.001), full flexion angle (R = 0.39, p 0.01), and range of knee motion (R = 0.38, p 0.01), but not full extension angle, varus laxity, or valgus laxity.Lubricin concentration was correlated with joint flexibility, but not with clinical symptoms, including pain at that time. |
| Databáze: | OpenAIRE |
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