Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies
| Autor: | Kathrine Kronberg Jakobsen, Anne Fischer-Nielsen, Christian von Buchwald, Christian Grønhøj, Thomas Hjuler, David Hebbelstrup Jensen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiology medicine.medical_treatment Respiratory System lcsh:Medicine Bioinformatics Pathology and Laboratory Medicine Regenerative medicine 0302 clinical medicine Fibrosis Animal Cells Bone Marrow Immune Physiology Medicine and Health Sciences Medicine lcsh:Science Immune Response Stenosis Multidisciplinary Larynx/pathology Stem Cells Stem Cell Therapy Stem-cell therapy Animal Models Trachea Treatment Outcome Mesenchymal Stem Cell Transplantation/methods Experimental Organism Systems 030220 oncology & carcinogenesis Larynx Cellular Types Anatomy Tracheal Stenosis Research Article medicine.medical_specialty Immunology Mouse Models Mesenchymal Stem Cell Transplantation Research and Analysis Methods Tracheal Stenosis/complications 03 medical and health sciences Signs and Symptoms Model Organisms Diagnostic Medicine Tissue Repair Animals Humans Inflammation Clinical Genetics business.industry Mesenchymal stem cell lcsh:R Biology and Life Sciences Mesenchymal Stem Cells Cell Biology medicine.disease Surgery 030104 developmental biology Immune System lcsh:Q business Laryngeal Stenosis Physiological Processes Laryngotracheal stenosis |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 9, p e0185283 (2017) Jakobsen, K K, Grønhøj, C, Jensen, D H, Fischer-Nielsen, A, Hjuler, T & von Buchwald, C 2017, ' Mesenchymal stem cell therapy for laryngotracheal stenosis : A systematic review of preclinical studies ', PLOS ONE, vol. 12, no. 9, e0185283 . https://doi.org/10.1371/journal.pone.0185283 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0185283 |
| Popis: | BACKGROUND: Laryngotracheal stenosis (LTS) can be either congenital or acquired. Laryngeal stenosis is most often encountered after prolonged intubation. The mechanism for stenosis following intubation is believed to be hypertrophic scarring. Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways.METHODS: PubMed, EMBASE, Google Scholar and the Cochrane Library were systematically searched from January 1980-January 2017 with the purpose of identifying all studies addressing the effect of MSC therapy on the airway. We assessed effect on inflammation, fibrosis, and MSC as a component in tissue engineering for treating defects in the airway.RESULTS: We identified eleven studies (n = 256 animals) from eight countries evaluating the effect of MSCs as a regenerative therapy in the upper airways. The studies indicate that MSC therapy may lead to a more constructive inflammatory response as well as support tissue regeneration.CONCLUSION: There may be a favorable effect of MSCs in inhibiting inflammation and as a component in tissue engineering. Given the heterogeneous nature of the included animal studies, any clear conclusion regarding the effect of tracheal stenosis in human subjects cannot be drawn. The included preclinical studies are however encouraging for further research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|