Serum concentrations of free indoxyl and p-cresyl sulfate are associated with mineral metabolism variables and cardiovascular risk in hemodialysis patients

Autor:	Teresa Arcidiacono, Lorenza Macrina, Simone Premaschi, Arianna Bologna, Giulia Magni, Nadia Foligno, Monica Avino, Cristina Belloni, Nicola Palmieri, Ferruccio Conte, Sergio Bisegna, Marco Simonini, Giorgio Slaviero, Massimo Locatelli, Giuseppe Vezzoli
Rok vydání:	2021
Předmět:	Minerals Indoles Sulfates Sulfuric Acid Esters Phosphates Cresols Nephrology Cardiovascular Diseases Heart Disease Risk Factors Renal Dialysis Risk Factors Humans Calcium Indican Biomarkers
Zdroj:	Journal of nephrology. 35(5)
ISSN:	1724-6059
Popis:	Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are uremic toxins associated with cardiovascular outcome in CKD patients. The present work is an analysis of the association of serum free, total IS and PCS with cardiovascular events and calcium-phosphate metabolism variables in hemodialysis patients.Serum levels of total and free IS and PCS were measured in 139 hemodialysis patients. Their relationship with calcium-phosphate metabolism variables were tested in an observational cohort study. In addition, their association with cardiovascular events was investigated during a 4-year follow-up.Patients in the highest tertile (T3) of serum free IS showed lower serum 1,25(OH)Serum free IS may be associated with PTH and 1,25(OH)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cd0284a7cda770d115c250ac0add56 https://pubmed.ncbi.nlm.nih.gov/35175580 Zobrazit plný text záznamu Full text from SpringerLink