Myxoid liposarcoma of the foot : a study of 8 cases
| Autor: | Elise M. Bekers, Johannes J. Bonenkamp, Uta Flucke, Marieke J.M. Ploegmakers, Pètra M. Braam, David Creytens, Bastiaan B J Tops, Joost van Gorp, Albert J. H. Suurmeijer, Thomas Mentzel, Ingrid C.M. van der Geest, Ingrid M.E. Desar, Wangzhao Song |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine EWSR1 rearrangement Pathology NEOPLASM FEATURES Thigh Translocation Genetic Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine PROGNOSTIC-FACTORS FUSION FUS rearrangement LIPOMA Sarcoma General Medicine Middle Aged Lipoma Acral site Prognosis Liposarcoma Myxoid medicine.anatomical_structure 030220 oncology & carcinogenesis Myxoid liposarcoma Female Lipoblastoma Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] MRI Adult medicine.medical_specialty Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] Round Cell Liposarcoma Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] Liposarcoma Pathology and Forensic Medicine 03 medical and health sciences medicine Journal Article Humans Aged ROUND-CELL LIPOSARCOMA Groin business.industry Foot medicine.disease Surgery Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] 030104 developmental biology LIPOBLASTOMA PATTERNS PRIMARY EXTREMITY LIPOSARCOMA Neoplasm Recurrence Local Ankle business |
| Zdroj: | Annals of Diagnostic Pathology, 25, 37-41 Annals of Diagnostic Pathology, 25, 37. W.B. Saunders Ltd Annals of Diagnostic Pathology, 25, pp. 37-41 Annals of Diagnostic Pathology, 25, 37-41. ELSEVIER SCIENCE INC |
| ISSN: | 1092-9134 |
| Popis: | Introduction: Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. We present a series of 8 cases occurring in the foot/ankle.Results: Two female and 6 male patients, aged between 32 and 77 years (mean, 54.3 years), were identified. Tumor size ranged from 1.1 to 10 cm (mean, 6.8 cm). Two lesions eroded bone. All tumors were treated by excision and 7 by (neo)adjuvant radiotherapy. R0 status was reached in 2 cases with 1 case followed by metastasis in the groin. All other cases were documented with R1 (n = 2) or R2 (n = 4) resection status. In 1 patient, the follow-up status was unknown. All other patients were alive 15-135 (mean, 55.8) months after initial diagnosis.We conclude that myxoid liposarcoma at acral sites are exceedingly rare, and in this series, prognosis was good irrespective of resection status. Clinicians and pathologists have to be aware because this sarcoma type shows a peculiar clinical behavior with high radio- and chemosensitivity and metastatic spread to extrapulmonary sites. (C) 2016 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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