The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis: a cross-sectional study
| Autor: | Mikkel Eld, Marius Henriksen, Olga Kubassova, A.C. Bay Jensen, Henrik Gudbergsen, J. Damm, Lars Arendt-Nielsen, R.G.C. Riis, Nasir Musa Al-Mashkur, Mikael Boesen, Kristian Kjær Petersen, Henning Bliddal, Ole Simonsen |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Biomedical Engineering Osteoarthritis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Outcome variable Rheumatology Synovitis Linear regression medicine Humans Orthopedics and Sports Medicine Stage (cooking) Aged 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Magnetic resonance imaging Histology Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Cross-Sectional Studies Female Radiology business |
| Zdroj: | Riis, R G C, Gudbergsen, H, Simonsen, O, Henriksen, M, Musa Al-Mashkur, N, Eld, M, Petersen, K K, Kubassova, O, Bay Jensen, A C, Damm, J, Bliddal, H, Arendt-Nielsen, L & Boesen, M P 2017, ' The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis : a cross-sectional study ', Osteoarthritis and Cartilage, vol. 25, no. 2, pp. 272-280 . https://doi.org/10.1016/j.joca.2016.10.006 |
| ISSN: | 1063-4584 |
| Popis: | Summary Objectives To investigate the association between magnetic resonance imaging (MRI), macroscopic and histological assessments of synovitis in end-stage knee osteoarthritis (KOA). Methods Synovitis of end-stage osteoarthritic knees was assessed using non-contrast-enhanced (CE), contrast-enhanced magnetic resonance imaging (CE-MRI) and dynamic contrast-enhanced (DCE)-MRI prior to (TKR) and correlated with microscopic and macroscopic assessments of synovitis obtained intraoperatively. Multiple bivariate correlations were used with a pre-specified threshold of 0.70 for significance. Also, multiple regression analyses with different subsets of MRI-variables as explanatory variables and the histology score as outcome variable were performed with the intention to find MRI-variables that best explain the variance in histological synovitis (i.e., highest R 2 ). A stepped approach was taken starting with basic characteristics and non-CE MRI-variables (model 1), after which CE-MRI-variables were added (model 2) with the final model also including DCE-MRI-variables (model 3). Results 39 patients (56.4% women, mean age 68 years, Kellgren–Lawrence (KL) grade 4) had complete MRI and histological data. Only the DCE-MRI variable MExNvoxel (surrogate of the volume and degree of synovitis) and the macroscopic score showed correlations above the pre-specified threshold for acceptance with histological inflammation. The maximum R 2 -value obtained in Model 1 was R 2 = 0.39. In Model 2, where the CE-MRI-variables were added, the highest R 2 = 0.52. In Model 3, a four-variable model consisting of the gender, one CE-MRI and two DCE-MRI-variables yielded a R 2 = 0.71. Conclusion DCE-MRI is correlated with histological synovitis in end-stage KOA and the combination of CE and DCE-MRI may be a useful, non-invasive tool in characterising synovitis in KOA. |
| Databáze: | OpenAIRE |
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