Frequent expression of interleukin-9 mRNA and infrequent involvement of interleukin-9 in proliferation of primary adult T-cell leukemia cells and HTLV-I infected T-cell lines
| Autor: | Hiroshi Fujiwara, Junko Fukumori, Hiromitsu Tanaka, Shiroh Hidaka, Kakushi Matsushita, Naomichi Arima, Hideo Ohtsubo |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Cancer Research Leukemia T-Cell T-Lymphocytes viruses medicine.medical_treatment T cell T-cell leukemia Biology medicine.disease_cause Virus immune system diseases hemic and lymphatic diseases Tumor Cells Cultured medicine Humans Interleukin 9 RNA Messenger Human T-lymphotropic virus 1 Interleukin-9 Hematology medicine.disease Leukemia Cytokine medicine.anatomical_structure Oncology Cell culture Immunology Cancer research Carcinogenesis Cell Division |
| Zdroj: | Leukemia Research. 21:211-216 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/s0145-2126(96)00109-9 |
| Popis: | To examine the possibility that interleukin-9 (IL-9) may be involved in oncogenesis and the proliferation of adult T-cell leukemia (ATL) cells, we examined the expression of IL-9 mRNA and growth response to IL-9 in five human T-lymphotropic virus type-I (HTLV-I) infected T-cell lines and in primary leukemia cells in peripheral blood from eight patients with ATL (four acute ATL and four chronic). Four out of five cell lines expressed IL-9 mRNA not correlated with Tax expression. Primary ATL cells from all patients also expressed IL-9 mRNA not correlated with the clinical forms. Recombinant IL-9 showed growth enhancing activity in only one out of five cell lines and one out of eight patients' primary leukemic cells. These results suggest the infrequent involvement of IL-9 in the proliferation of ATL cells, both primary tumor cells and HTLV-I infected T-cell lines. |
| Databáze: | OpenAIRE |
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