Human Corneal Endothelial Cells Expanded In Vitro Are a Powerful Resource for Tissue Engineering
| Autor: | Yongsong Liu, Shuangling Chen, Sean Tighe, Ping Guo, Hong Sun, Min Zhu, Subo Cai, Yuan Zhang, Chen-Wei Su, Min Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
genetic structures Review Cornea 03 medical and health sciences Tissue engineering In vivo endothelial medicine Humans Endothelial dysfunction Barrier function Cells Cultured Progenitor Cell Proliferation Tissue Engineering business.industry Endothelial Cells progenitor General Medicine Anatomy medicine.disease In vitro eye diseases Cell biology Transplantation 030104 developmental biology medicine.anatomical_structure sense organs business regenerative medical application |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Human corneal endothelial cells have two major functions: barrier function mediated by proteins such as ZO-1 and pump function mediated by Na-K-ATPase which help to maintain visual function. However, human corneal endothelial cells are notorious for their limited proliferative capability in vivo and are therefore prone to corneal endothelial dysfunction that eventually may lead to blindness. At present, the only method to cure corneal endothelial dysfunction is by transplantation of a cadaver donor cornea with normal corneal endothelial cells. Due to the global shortage of donor corneas, it is vital to engineer corneal tissue in vitro that could potentially be transplanted clinically. In this review, we summarize the advances in understanding the behavior of human corneal endothelial cells, their current engineering strategy in vitro and their potential applications. |
| Databáze: | OpenAIRE |
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