Parengyodontium album Isolated from Cutaneous Lesions of a Pacific White-Sided Dolphin (Lagenorhynchus obliquidens) During Treatment for Paracoccidioidomycosis Ceti
| Autor: | Yuichi Nakamura, Nanako Tomino, Ayako Sano, Eiko Nakagawa Itano, Hikaru Kanegae, Takashi Yaguchi, Keiichi Ueda, Takeshi Izawa, Tomoko Minakawa |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Opportunistic infection Veterinary (miscellaneous) Lagenorhynchus obliquidens Dolphins 030106 microbiology Applied Microbiology and Biotechnology Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Medical microbiology Japan Genotype medicine Animals Skin Diseases Infectious Mycosis biology medicine.diagnostic_test Paracoccidioidomycosis medicine.disease biology.organism_classification Skin biopsy Hypocreales Immune disorder Agronomy and Crop Science |
| Zdroj: | Mycopathologia. 185(6) |
| ISSN: | 1573-0832 |
| Popis: | The prominence of seafood in Japan motivates close monitoring of its seas and marine lives for potentially pathogenic fungi. During the treatments of the male Pacific white-sided dolphin (Lagenorhynchus obliquidens) for paracoccidioidomycosis ceti (PCM-C), 5 white and floccose colonies showing identical genotype and morphological characteristics were isolated from two skin biopsy samples of cutaneous granulomatous lesions in 2018. The isolates were identified as Parengyodontium album known as one of fungal species having abilities to produce industrially important proteases, and to become a causative agent for emerging mycosis based on morphological and molecular biological characteristics. These lesions consisted of non-malignant pearl-like structures of hyperplastic keratinocytes. Interestingly, although the isolates could grow at 35 °C, their DNA sequences were phylogenetically located in a cluster consisting of environmental and clinical isolates lacking the ability to grow at 35 °C, based on previous reports. The opportunistic infection we observed in the dolphin might be caused by immune disorder due to PCM-C. Notably, although P. album is recognized as non-harmful, and has significant industrial importance and antitumor activity, it has potential to cause not only superficial but also systemic infection, and presents difficulties in treatment because of its high resistance to antifungal compounds. |
| Databáze: | OpenAIRE |
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