Synthesis of Indium-Containing Nanoparticles in Aqueous Suspension Using Plasmas in Water for Evaluating Their Kinetics in Living Body
| Autor: | Miyuki Hirata, Thapanut Sarinont, Kazunori Koga, Takaaki Amano, Akiyo Tanaka, Masaharu Shiratani |
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| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
Materials science Plasma Gases Diffusion Kinetics Biomedical Engineering Analytical chemistry Metal Nanoparticles chemistry.chemical_element Nanoparticle Bioengineering Indium law.invention Mice Colloid chemistry.chemical_compound law Materials Testing Animals Tissue Distribution General Materials Science Colloids Particle Size Crystallization Skin digestive oral and skin physiology Water General Chemistry respiratory system Condensed Matter Physics chemistry Hydroxide Particle size Blood Chemical Analysis circulatory and respiratory physiology Nuclear chemistry |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 15:9298-9302 |
| ISSN: | 1533-4899 1533-4880 |
| Popis: | Nanoparticles have great potential for medical applications such as cancer therapy, whereas their toxic effects on human body are pointed out. To study kinetics and toxicity of nanoparticles in living body, we synthesized indium-containing nanoparticles in aqueous suspension using pulsed electrical discharge plasmas in water, because no indium compounds exist in the living body in the normal situation and hence indium-containing nanoparticles are useful tracer materials for analyzing kinetics of nanoparticles in living body. The mean size of synthesized primary nanoparticles is 7 nm, whereas the mean size of secondary nanoparticles is 315 nm. EDX and XRD analysis reveal that nanoparticles are indium crystalline and indium hydroxide crystalline with the mass ratio of 8:2. Preliminary subcutaneous administration of nanoparticles to mice shows that indium is transported from subcutaneous to blood. These results show that synthesized indium-containing nanoparticles are useful for analyzing kinetics of nanoparticles in living body. |
| Databáze: | OpenAIRE |
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