Palliation Plus Ventricular Assist Device Insertion in 15 Neonates and Infants With Functionally Univentricular Circulation
| Autor: | Mark S. Bleiweis, Joseph Philip, Giles J. Peek, James C. Fudge, Kevin J. Sullivan, Jennifer Co-Vu, Dipankar Gupta, Renata Shih, Biagio 'Bill' A. Pietra, Frederick Jay Fricker, Himesh V. Vyas, Jose F. Hernandez-Rivera, Emma R. Powers, Connie S. Nixon, Matheus Falasa, Jeffrey Phillip Jacobs |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Heart Defects Congenital Pulmonary Circulation Palliative Care Infant Newborn Infant Fontan Procedure Young Adult Treatment Outcome Hypoplastic Left Heart Syndrome Humans Surgery Heart-Assist Devices Cardiology and Cardiovascular Medicine Retrospective Studies |
| Zdroj: | The Annals of thoracic surgery. 114(4) |
| ISSN: | 1552-6259 |
| Popis: | We report 15 high-risk neonates and infants with functionally univentricular circulation stabilized with initial surgical palliation plus ventricular assist device (VAD) insertion (PALLIATION+VAD) in preparation for transplantation.Fifteen functionally univentricular patients with ductal-dependent systemic circulation (8 hypoplastic left heart syndrome, 1 hypoplastic left heart syndrome-related malformation: 7 neonates, 2 infants) or ductal-dependent pulmonary circulation (6 hypoplastic right heart syndrome: 5 neonates, 1 infant) presented with anatomical and/or physiological features associated with increased risk for conventional univentricular palliation (large coronary sinusoids with ventricular-dependent coronary circulation, severe systemic atrioventricular valvar regurgitation, cardiogenic shock, or restrictive atrial septum). PALLIATION+VAD for patients with ductal-dependent systemic circulation was: VAD insertion plus application of bilateral pulmonary bands, stent placement in the arterial duct, and atrial septectomy, if needed. PALLIATION+VAD for patients with ductal-dependent pulmonary circulation was: VAD insertion plus stent placement in the arterial duct or systemic-to-pulmonary artery shunt with pulmonary arterioplasty, if needed.At PALLIATION+VAD, median age was 20 days (range, 4-143 days) and median weight was 3.47 kg (range, 2.43-4.86 kg). Ten patients (67%) survived and 5 patients (33%) died. All ten survivors are at home doing well after successful transplantation. Only 2 of 10 survivors (20%) required intubation10 days after PALLIATION+VAD. Median length of VAD support for all 15 patients was 138 days (range, 56-226 days).High-risk neonates with functionally univentricular hearts who are suboptimal candidates for conventional palliation can be successfully stabilized with pulsatile VAD insertion along with initial palliation while awaiting cardiac transplantation; these patients may be extubated, enterally nourished, and optimized for transplantation while on VAD. |
| Databáze: | OpenAIRE |
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